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EMD-29220
CryoEM structure of HLA-A2 MAGEA4 (230-239) in complex with REGN6972 Fab and 2M2 Fab
EMD-29220
Single-particle3.0 Å
Deposition: 19/12/2022Map released: 20/12/2023
Last modified: 21/05/2025
Sample Organism:
Homo sapiens
Sample: HLA-A2 MAGEA4 (230-239) in complex with REGN6972 Fab and 2M2 Fab
Fitted models: 8fja
Deposition Authors: Saotome K, Franklin MC
Sample: HLA-A2 MAGEA4 (230-239) in complex with REGN6972 Fab and 2M2 Fab
Fitted models: 8fja
Deposition Authors: Saotome K, Franklin MC
CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo.
Salzler R ,
DiLillo DJ ,
Saotome K,
Bray K ,
Mohrs K ,
Hwang H,
Cygan KJ ,
Shah D ,
Rye-Weller A,
Kundu K ,
Badithe A,
Zhang X ,
Garnova E ,
Torres M ,
Dhanik A ,
Babb R,
Delfino FJ ,
Thwaites C ,
Dudgeon D ,
Moore MJ ,
Meagher TC ,
Decker CE ,
Owczarek T ,
Gleason JA,
Yang X ,
Suh D ,
Lee WY ,
Welsh R ,
MacDonald D ,
Hansen J ,
Guo C ,
Kirshner JR ,
Thurston G ,
Huang T ,
Franklin MC ,
Yancopoulos GD,
Lin JC ,
Macdonald LE ,
Murphy AJ ,
Chen G,
Olsen O ,
Olson WC
(2025) Sci Transl Med , 17 , eado9371 - eado9371
,
DiLillo DJ ,
Saotome K,
Bray K ,
Mohrs K ,
Hwang H,
Cygan KJ ,
Shah D ,
Rye-Weller A,
Kundu K ,
Badithe A,
Zhang X ,
Garnova E ,
Torres M ,
Dhanik A ,
Babb R,
Delfino FJ ,
Thwaites C ,
Dudgeon D ,
Moore MJ ,
Meagher TC ,
Decker CE ,
Owczarek T ,
Gleason JA,
Yang X ,
Suh D ,
Lee WY ,
Welsh R ,
MacDonald D ,
Hansen J ,
Guo C ,
Kirshner JR ,
Thurston G ,
Huang T ,
Franklin MC ,
Yancopoulos GD,
Lin JC ,
Macdonald LE ,
Murphy AJ ,
Chen G,
Olsen O ,
Olson WC
(2025) Sci Transl Med , 17 , eado9371 - eado9371
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