Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-28793

Single-particle
2.92 Å
EMD-28793
3D View Gallery
Deposition: 04/11/2022
Map released: 25/10/2023
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28793
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8f1c summary report (pdf.gz) Map and 8f1c FULL report (pdf.gz)
EMICSS annotations (xml)

Voltage-gated potassium channel Kv3.1 with novel positive modulator (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one (compound 4)

EMD-28793

Single-particle
2.92 Å
EMD-28793
3D View Gallery
Deposition: 04/11/2022
Map released: 25/10/2023
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: potassium voltage-gated channel
Fitted models: 8f1c

Deposition Authors: Chen Y, Ishchenko A
Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels.
Chen YT, Hong MR , Zhang XJ , Kostas J, Li Y , Kraus RL , Santarelli VP , Wang D , Gomez-Llorente Y, Brooun A, Strickland C, Soisson SM , Klein DJ , Ginnetti AT, Marino MJ , Stachel SJ , Ishchenko A
(2023) PNAS , 120 , e2220029120 - e2220029120
PUBMED: 37812700
DOI: doi:10.1073/pnas.2220029120
ISSN: 1091-6490
ASTM: PNASA6
Grant Support: