EMD-28664

Single-particle
3.77 Å
EMD-28664
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Deposition: 26/10/2022
Map released: 04/09/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-28664
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Herpes simplex virus 1 DNA polymerase holoenzyme bound to DNA template and primer, dNTP-free (editing mode)

EMD-28664

Single-particle
3.77 Å
EMD-28664
3D View Gallery
Deposition: 26/10/2022
Map released: 04/09/2024
Last modified: 16/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Human alphaherpesvirus 1 strain KOS, synthetic construct
Sample: HSV-1 polymerase holoenzyme UL30:UL42 in complex with template and primer DNA (no mismatch), dNTP free

Deposition Authors: Pan J , Abraham J , Coen DM , Shankar S, Yang P, Hogle J
Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.
Shankar S, Pan J , Yang P, Bian Y, Oroszlan G, Yu Z, Mukherjee P , Filman DJ, Hogle JM, Shekhar M, Coen DM , Abraham J
(2024) Cell , 187 , 5572 - 5586.e15
PUBMED: 39197451
DOI: doi:10.1016/j.cell.2024.07.048
ISSN: 1097-4172