Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-28228
SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment
EMD-28228
Single-particle3.6 Å
Deposition: 24/09/2022Map released: 19/07/2023
Last modified: 06/11/2024
Sample Organism:
Homo sapiens,
Severe acute respiratory syndrome coronavirus 2
Sample: SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 antibody Fab fragment
Fitted models: 8elj
Deposition Authors: Yee AW, Morizumi T, Kim K, Kuo A, Ernst OP
Sample: SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 antibody Fab fragment
Fitted models: 8elj
Deposition Authors: Yee AW, Morizumi T, Kim K, Kuo A, Ernst OP
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.
Hermet P ,
Delache B,
Herate C ,
Wolf E,
Kivi G,
Juronen E,
Mumm K,
Zusinaite E,
Kainov D ,
Sankovski E,
Virumae K,
Planken A,
Merits A ,
Besaw JE,
Yee AW,
Morizumi T,
Kim K,
Kuo A,
Berriche A,
Dereuddre-Bosquet N,
Sconosciuti Q,
Naninck T,
Relouzat F,
Cavarelli M,
Ustav M,
Wilson D,
Ernst OP ,
Mannik A,
LeGrand R,
Ustav Jr M
(2023) PLoS Pathog , 19 , e1011532 - e1011532
,
Delache B,
Herate C ,
Wolf E,
Kivi G,
Juronen E,
Mumm K,
Zusinaite E,
Kainov D ,
Sankovski E,
Virumae K,
Planken A,
Merits A ,
Besaw JE,
Yee AW,
Morizumi T,
Kim K,
Kuo A,
Berriche A,
Dereuddre-Bosquet N,
Sconosciuti Q,
Naninck T,
Relouzat F,
Cavarelli M,
Ustav M,
Wilson D,
Ernst OP ,
Mannik A,
LeGrand R,
Ustav Jr M
(2023) PLoS Pathog , 19 , e1011532 - e1011532
Grant Support:
- Canada Excellence Research Chair Award: (Canada)