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EMD-27730
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432
EMD-27730
Single-particle3.4 Å
Deposition: 27/07/2022Map released: 31/08/2022
Last modified: 06/11/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Homo sapiens
Sample: SARS-CoV-2 Wuhan-hu-1-Spike bound to linker variant of affinity matured ACE2 mimetic CVD432
Fitted models: 8dv1
Deposition Authors: QCRG Structural Biology Consortium, Remesh SG, Merz GE, Brilot AF, Chio U, Verba KA
Sample: SARS-CoV-2 Wuhan-hu-1-Spike bound to linker variant of affinity matured ACE2 mimetic CVD432
Fitted models: 8dv1
Deposition Authors: QCRG Structural Biology Consortium, Remesh SG, Merz GE, Brilot AF, Chio U, Verba KA
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
Remesh SG,
Merz GE,
Brilot AF,
Chio US,
Rizo AN,
Pospiech Jr TH,
Lui I,
Laurie MT,
Glasgow J,
Le CQ,
Zhang Y,
Diwanji D,
Hernandez E,
Lopez J 
,
Mehmood H ,
Pawar KI,
Pourmal S,
Smith AM,
Zhou F,
DeRisi J,
Kortemme T,
Rosenberg OS,
Glasgow A,
Leung KK,
Wells JA,
Verba KA
(2023) Structure , 31 , 253
,
Mehmood H ,
Pawar KI,
Pourmal S,
Smith AM,
Zhou F,
DeRisi J,
Kortemme T,
Rosenberg OS,
Glasgow A,
Leung KK,
Wells JA,
Verba KA
(2023) Structure , 31 , 253
Grant Support:
- Department of Defense (DOD, United States): HR0011-19-2-0020 (United States)
- Chan Zuckerberg Initiative: (United States)
- Mercatus Center: Emergent Ventures #2154 (United States)