EMD-27588

Single-particle
2.95 Å
EMD-27588
3D View Gallery
Deposition: 12/07/2022
Map released: 24/05/2023
Last modified: 06/09/2023
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-27588
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8do2 summary report (pdf.gz) Map and 8do2 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA)

EMD-27588

Single-particle
2.95 Å
EMD-27588
3D View Gallery
Deposition: 12/07/2022
Map released: 24/05/2023
Last modified: 06/09/2023
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: A human-yeast chimeric Sec complex treated with cyclotriazadisulfonamide (CADA)
Fitted models: 8do2

Deposition Authors: Park E , Itskanov S
A common mechanism of Sec61 translocon inhibition by small molecules.
Itskanov S , Wang L , Junne T, Sherriff R , Xiao L, Blanchard N , Shi WQ , Forsyth C, Hoepfner D , Spiess M , Park E
(2023) Nat Chem Biol , 19 , 1063 - 1071
PUBMED: 37169959
DOI: doi:10.1038/s41589-023-01337-y
ISSN: 1552-4469
Grant Support: