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EMD-27098
Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with extended HR2
EMD-27098
Single-particle2.22 Å
Deposition: 24/05/2022Map released: 07/09/2022
Last modified: 12/06/2024
Sample Organism:
Severe acute respiratory syndrome coronavirus 2
Sample: SARS-CoV-2 HR1HR2 complex
Fitted models: 8czi
Deposition Authors: Yang K
,
Brunger AT
Sample: SARS-CoV-2 HR1HR2 complex
Fitted models: 8czi
Deposition Authors: Yang K
,
Brunger AT
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
Yang K ,
Wang C ,
Kreutzberger AJB,
Ojha R ,
Kuivanen S,
Couoh-Cardel S ,
Muratcioglu S,
Eisen TJ,
White KI ,
Held RG ,
Subramanian S ,
Marcus K ,
Pfuetzner RA,
Esquivies L ,
Doyle CA ,
Kuriyan J,
Vapalahti O ,
Balistreri G ,
Kirchhausen T,
Brunger AT
(2022) PNAS , 119 , e2210990119 - e2210990119
,
Wang C ,
Kreutzberger AJB,
Ojha R ,
Kuivanen S,
Couoh-Cardel S ,
Muratcioglu S,
Eisen TJ,
White KI ,
Held RG ,
Subramanian S ,
Marcus K ,
Pfuetzner RA,
Esquivies L ,
Doyle CA ,
Kuriyan J,
Vapalahti O ,
Balistreri G ,
Kirchhausen T,
Brunger AT
(2022) PNAS , 119 , e2210990119 - e2210990119
Grant Support:
- Howard Hughes Medical Institute (HHMI): (United States)