EMD-26664
Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG
EMD-26664
Helical reconstruction3.3 Å
Deposition: 15/04/2022Map released: 28/09/2022
Last modified: 14/05/2025
Sample Organism:
Homo sapiens
Sample: Tau Alzheimer's Disease Paired Helical Filament incubated 1 hr. with EGCG
Fitted models: 7upf
Deposition Authors: Seidler PM, Murray KA, Boyer DR
,
Ge P ,
Sawaya MR ,
Eisenberg DS
Sample: Tau Alzheimer's Disease Paired Helical Filament incubated 1 hr. with EGCG
Fitted models: 7upf
Deposition Authors: Seidler PM, Murray KA, Boyer DR
,
Ge P ,
Sawaya MR ,
Eisenberg DS
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Seidler PM,
Murray KA,
Boyer DR ,
Ge P ,
Sawaya MR ,
Hu CJ ,
Cheng X,
Abskharon R,
Pan H ,
DeTure MA,
Williams CK,
Dickson DW ,
Vinters HV,
Eisenberg DS
(2022) Nat Commun , 13 , 5451 - 5451
,
Ge P ,
Sawaya MR ,
Hu CJ ,
Cheng X,
Abskharon R,
Pan H ,
DeTure MA,
Williams CK,
Dickson DW ,
Vinters HV,
Eisenberg DS
(2022) Nat Commun , 13 , 5451 - 5451
Grant Support:
- National Institutes of Health/National Institute on Aging (NIH/NIA): 1R01 AG029430 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): AG061847 (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): RF1 AG054022 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): 1F32 NS095661 (United States)