EMD-26160

Single-particle
3.0 Å
EMD-26160
3D View Gallery
Deposition: 09/02/2022
Map released: 15/03/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-26160
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7txt summary report (pdf.gz) Map and 7txt FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl

EMD-26160

Single-particle
3.0 Å
EMD-26160
3D View Gallery
Deposition: 09/02/2022
Map released: 15/03/2023
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: Human serotonin transporter in complex with Fab15B8 bound to '8090 in NaCl
Fitted models: 7txt

Deposition Authors: Singh I, Seth A
Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
Singh I, Seth A, Billesbolle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V , Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A, Shoichet BK, Rudnick G
(2023) Cell , 186 , 2160 - 2175.e17
PUBMED: 37137306
DOI: doi:10.1016/j.cell.2023.04.010
ISSN: 1097-4172