EMD-25581

Single-particle
8.7 Å
EMD-25581
3D View Gallery
Deposition: 30/11/2021
Map released: 12/01/2022
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25581
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7t0o summary report (pdf.gz) Map and 7t0o FULL report (pdf.gz)
EMICSS annotations (xml)

cryoEM reconstruction of the HIV gp140 in complex with the extracellular domains of CD4 and the adnectin domain of Combinectin. The gp140 and CD4 coordinates from entry 6EDU were rigid body fitted to the EM map along withe the crystal structure of CD4+adnectin

EMD-25581

Single-particle
8.7 Å
EMD-25581
3D View Gallery
Deposition: 30/11/2021
Map released: 12/01/2022
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: HIV-1 06TG.HT008, Homo sapiens
Sample: Ternary complex of the HIV-1 gp140 trimer in complex with the extracellular domains (domains 1-4) of CD4 and an adnectin domain of Combinectin
Fitted models: 7t0o

Deposition Authors: Concha NO, William SP
Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment.
Wensel D , Williams S, Dixon DP, Ward P, McCormick P, Concha N, Stewart E , Hong X, Mazzucco C, Pal S, Ding B, Fellinger C , Krystal M
(2021) J Mol Biol , 434 , 167395 - 167395
PUBMED: 34896364
DOI: doi:10.1016/j.jmb.2021.167395
ISSN: 1089-8638
ASTM: JMOBAK
Grant Support: