Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-25524

Single-particle
4.2 Å
EMD-25524
3D View Gallery
Deposition: 24/11/2021
Map released: 27/07/2022
Last modified: 28/02/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25524
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7syf summary report (pdf.gz) Map and 7syf FULL report (pdf.gz)
EMICSS annotations (xml)

Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)

EMD-25524

Single-particle
4.2 Å
EMD-25524
3D View Gallery
Deposition: 24/11/2021
Map released: 27/07/2022
Last modified: 28/02/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)
Fitted models: 7syf

Deposition Authors: Lupton CJ , Bayly-Jones C
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Chang YG , Lupton CJ , Bayly-Jones C , Keen AC , D'Andrea L , Lucato CM, Steele JR , Venugopal H , Schittenhelm RB , Whisstock JC, Halls ML , Ellisdon AM
(2022) Nat Struct Mol Biol , 29 , 767 - 773
PUBMED: 35864164
DOI: doi:10.1038/s41594-022-00804-9
ISSN: 1545-9985