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EMD-25142

Single-particle
3.45 Å
EMD-25142
3D View Gallery
Deposition: 14/10/2021
Map released: 02/02/2022
Last modified: 05/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-25142
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7sii summary report (pdf.gz) Map and 7sii FULL report (pdf.gz)
EMICSS annotations (xml)

Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53)

EMD-25142

Single-particle
3.45 Å
EMD-25142
3D View Gallery
Deposition: 14/10/2021
Map released: 02/02/2022
Last modified: 05/06/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human STING
Fitted models: 7sii

Deposition Authors: Lu D, Shang G
Activation of STING by targeting a pocket in the transmembrane domain.
Lu D, Shang G, Li J , Lu Y , Bai XC, Zhang X
(2022) Nature , 604 , 557 - 562
PUBMED: 35388221
DOI: doi:10.1038/s41586-022-04559-7
ISSN: 1476-4687
ASTM: NATUAS