Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-23951
The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
EMD-23951
Single-particle4.4 Å
Deposition: 06/05/2021Map released: 16/03/2022
Last modified: 23/10/2024
Sample Organism:
Homo sapiens
Sample: Insulin receptor ectodomain in complex with insulin analog Vh-Ins-HSLQ - asymmetric conformation.
Fitted models: 7mqs
Deposition Authors: Blakely AD, Xiong X
Sample: Insulin receptor ectodomain in complex with insulin analog Vh-Ins-HSLQ - asymmetric conformation.
Fitted models: 7mqs
Deposition Authors: Blakely AD, Xiong X
Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Xiong X ,
Blakely A ,
Kim JH,
Menting JG,
Schafer IB ,
Schubert HL,
Agrawal R,
Gutmann T ,
Delaine C,
Zhang YW ,
Artik GO ,
Merriman A,
Eckert D,
Lawrence MC ,
Coskun U ,
Fisher SJ,
Forbes BE ,
Safavi-Hemami H ,
Hill CP ,
Chou DH
(2022) Nat Chem Biol , 18 , 511 - 519
,
Blakely A ,
Kim JH,
Menting JG,
Schafer IB ,
Schubert HL,
Agrawal R,
Gutmann T ,
Delaine C,
Zhang YW ,
Artik GO ,
Merriman A,
Eckert D,
Lawrence MC ,
Coskun U ,
Fisher SJ,
Forbes BE ,
Safavi-Hemami H ,
Hill CP ,
Chou DH
(2022) Nat Chem Biol , 18 , 511 - 519
Grant Support: