Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-22909
SARS-CoV-2 Spike bound to Nb11 in closed conformation
EMD-22909
Single-particle4.18 Å
Deposition: 27/10/2020Map released: 11/11/2020
Last modified: 21/04/2021
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
synthetic construct
Sample: Complex of Spike S2P glycoprotein with synthetic nanobody Nb11
Deposition Authors: Schoof MS, Faust BF, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesboelle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Desphande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, Garcia-Sastre A, Ott M, Vignuzzi M, Walter P, Manglik A, QCRG Structural Biology Consortium
Sample: Complex of Spike S2P glycoprotein with synthetic nanobody Nb11
Deposition Authors: Schoof MS, Faust BF, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesboelle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Desphande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, Garcia-Sastre A, Ott M, Vignuzzi M, Walter P, Manglik A, QCRG Structural Biology Consortium
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Schoof M 
,
Faust B ,
Saunders RA ,
Sangwan S ,
Rezelj V,
Hoppe N ,
Boone M ,
Billesbolle CB ,
Puchades C ,
Azumaya CM ,
Kratochvil HT ,
Zimanyi M ,
Deshpande I ,
Liang J ,
Dickinson S,
Nguyen HC ,
Chio CM ,
Merz GE ,
Thompson MC ,
Diwanji D ,
Schaefer K ,
Anand AA ,
Dobzinski N ,
Zha BS ,
Simoneau CR,
Leon K ,
White KM,
Chio US ,
Gupta M ,
Jin M ,
Li F ,
Liu Y,
Zhang K ,
Bulkley D ,
Sun M ,
Smith AM ,
Rizo AN ,
Moss F,
Brilot AF ,
Pourmal S ,
Trenker R ,
Pospiech T,
Gupta S,
Barsi-Rhyne B,
Belyy V ,
Barile-Hill AW,
Nock S,
Liu Y,
Krogan NJ ,
Ralston CY,
Swaney DL ,
Garcia-Sastre A ,
Ott M,
Vignuzzi M,
QCRG Structural Biology Consortium,
Walter P ,
Manglik A
(2020) Science , 370 , 1473 - 1479
,
Faust B ,
Saunders RA ,
Sangwan S ,
Rezelj V,
Hoppe N ,
Boone M ,
Billesbolle CB ,
Puchades C ,
Azumaya CM ,
Kratochvil HT ,
Zimanyi M ,
Deshpande I ,
Liang J ,
Dickinson S,
Nguyen HC ,
Chio CM ,
Merz GE ,
Thompson MC ,
Diwanji D ,
Schaefer K ,
Anand AA ,
Dobzinski N ,
Zha BS ,
Simoneau CR,
Leon K ,
White KM,
Chio US ,
Gupta M ,
Jin M ,
Li F ,
Liu Y,
Zhang K ,
Bulkley D ,
Sun M ,
Smith AM ,
Rizo AN ,
Moss F,
Brilot AF ,
Pourmal S ,
Trenker R ,
Pospiech T,
Gupta S,
Barsi-Rhyne B,
Belyy V ,
Barile-Hill AW,
Nock S,
Liu Y,
Krogan NJ ,
Ralston CY,
Swaney DL ,
Garcia-Sastre A ,
Ott M,
Vignuzzi M,
QCRG Structural Biology Consortium,
Walter P ,
Manglik A
(2020) Science , 370 , 1473 - 1479
Grant Support:
- Other private: (United States)