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EMD-22663
Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a
EMD-22663
Single-particle3.1 Å
Deposition: 15/09/2020Map released: 09/12/2020
Last modified: 21/05/2025
Sample Organism:
Homo sapiens
Sample: sample 1
Fitted models: 7k4b
Deposition Authors: Neuberger A
,
Nadezhdin KD
Sample: sample 1
Fitted models: 7k4b
Deposition Authors: Neuberger A
,
Nadezhdin KD
Inactivation-mimicking block of the epithelial calcium channel TRPV6.
Bhardwaj R ,
Lindinger S ,
Neuberger A ,
Nadezhdin KD ,
Singh AK,
Cunha MR ,
Derler I ,
Gyimesi G ,
Reymond JL ,
Hediger MA ,
Romanin C ,
Sobolevsky AI
(2020) Sci Adv , 6
,
Lindinger S ,
Neuberger A ,
Nadezhdin KD ,
Singh AK,
Cunha MR ,
Derler I ,
Gyimesi G ,
Reymond JL ,
Hediger MA ,
Romanin C ,
Sobolevsky AI
(2020) Sci Adv , 6
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01 CA206573 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS083660 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS107253 (United States)
- National Science Foundation (NSF, United States): 1818086 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM103310 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): P30 GM124165 (United States)