Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-22429

Single-particle
3.4 Å
EMD-22429
3D View Gallery
Deposition: 10/08/2020
Map released: 28/07/2021
Last modified: 15/09/2021
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-22429
Download
3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7mwe summary report (pdf.gz) Map and 7mwe FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human HUWE1 (focused on WWE)

EMD-22429

Single-particle
3.4 Å
EMD-22429
3D View Gallery
Deposition: 10/08/2020
Map released: 28/07/2021
Last modified: 15/09/2021
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: E3 ubiquitin-protein ligase HUWE1
Fitted models: 7mwe

Deposition Authors: Hunkeler M, Fischer ES
Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Hunkeler M, Jin CY, Ma MW, Monda JK, Overwijn D , Bennett EJ, Fischer ES
(2021) Mol. Cell , 81 , 3468 - 3480.e7
PUBMED: 34314700
DOI: doi:10.1016/j.molcel.2021.06.032
ISSN: 1097-2765
ASTM: MOCEFL