EMD-22259
Human 20S proteasome bound to an engineered 11S (PA26) activator
EMD-22259
Single-particle3.0 Å
Deposition: 30/06/2020Map released: 22/07/2020
Last modified: 15/05/2024
Sample Organism:
Homo sapiens,
Trypanosoma brucei
Sample: PA26-bound proteasome
Fitted models: 6xmj
Deposition Authors: de la Pena AH
,
Opoku-Nsiah KA ,
Williams SK ,
Chopra N,
Sali A ,
Gestwicki JE ,
Lander GC
Sample: PA26-bound proteasome
Fitted models: 6xmj
Deposition Authors: de la Pena AH
,
Opoku-Nsiah KA ,
Williams SK ,
Chopra N,
Sali A ,
Gestwicki JE ,
Lander GC
The Y Phi motif defines the structure-activity relationships of human 20S proteasome activators.
Opoku-Nsiah KA ,
de la Pena AH ,
Williams SK ,
Chopra N,
Sali A ,
Lander GC ,
Gestwicki JE
(2022) Nat Commun , 13 , 1226 - 1226
,
de la Pena AH ,
Williams SK ,
Chopra N,
Sali A ,
Lander GC ,
Gestwicki JE
(2022) Nat Commun , 13 , 1226 - 1226
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): DP2-EB020402 (United States)
- American Cancer Society: 132279-PF-18-189-01- DMC (United States)