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EMD-22106
High resolution cryoEM structure of huntingtin in complex with HAP40
EMD-22106
Single-particle2.6 Å
Deposition: 03/06/2020Map released: 17/06/2020
Last modified: 28/05/2025
Sample Organism:
Homo sapiens
Sample: Human huntingtin-HAP40 complex
Fitted models: 6x9o
Deposition Authors: Harding RJ
,
Deme JC ,
Lea SM ,
Arrowsmith CH ,
Structural Genomics Consortium (SGC)
Sample: Human huntingtin-HAP40 complex
Fitted models: 6x9o
Deposition Authors: Harding RJ
,
Deme JC ,
Lea SM ,
Arrowsmith CH ,
Structural Genomics Consortium (SGC)
Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.
Harding RJ ,
Deme JC ,
Hevler JF,
Tamara S ,
Lemak A,
Cantle JP ,
Szewczyk MM,
Begeja N,
Goss S,
Zuo X ,
Loppnau P,
Seitova A,
Hutchinson A,
Fan L,
Truant R,
Schapira M ,
Carroll JB,
Heck AJR ,
Lea SM ,
Arrowsmith CH
(2021) Commun Biol , 4 , 1374 - 1374
,
Deme JC ,
Hevler JF,
Tamara S ,
Lemak A,
Cantle JP ,
Szewczyk MM,
Begeja N,
Goss S,
Zuo X ,
Loppnau P,
Seitova A,
Hutchinson A,
Fan L,
Truant R,
Schapira M ,
Carroll JB,
Heck AJR ,
Lea SM ,
Arrowsmith CH
(2021) Commun Biol , 4 , 1374 - 1374