EMD-19986

Helical reconstruction
1.93 Å
EMD-19986
3D View Gallery
Deposition: 28/03/2024
Map released: 05/06/2024
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19986
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9euu summary report (pdf.gz) Map and 9euu FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo

EMD-19986

Helical reconstruction
1.93 Å
EMD-19986
3D View Gallery
Deposition: 28/03/2024
Map released: 05/06/2024
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: recombinant alpha-synuclein fibril
Fitted models: 9euu

Deposition Authors: Burger D, Kashyrina M, Lewis A, De Nuccio F, Mohammed I, de La Seigliere H, van den Heuvel L, Feuillie C, Verchere J, Berbon M, Arotcarena M, Retailleau A, Bezard E, Laferriere F, Loquet A, Bousset L, Baron T, Lofrumento DD, De Giorgi F, Stahlberg H, Ichas F
Synthetic alpha-synuclein fibrils replicate in mice causing MSA-like pathology.
Burger D, Kashyrina M, van den Heuvel L, de La Seigliere H, Lewis AJ, De Nuccio F, Mohammed I, Verchere J, Feuillie C, Berbon M, Arotcarena ML, Retailleau A, Bezard E, Canron MH, Meissner WG, Loquet A, Bousset L, Poujol C, Nilsson KPR, Laferriere F, Baron T, Lofrumento DD, De Giorgi F, Stahlberg H, Ichas F
(2025) Nature , 648 , 409 - 417
PUBMED: 41193804
DOI: doi:10.1038/s41586-025-09698-1
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: