EMD-19628

Single-particle
2.3 Å
EMD-19628
3D View Gallery
Deposition: 14/02/2024
Map released: 25/12/2024
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-19628

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8s0t summary report (pdf.gz) Map-8s0t FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of CAK in complex with SY-5609

EMD-19628

Single-particle
2.3 Å
EMD-19628
3D View Gallery
Deposition: 14/02/2024
Map released: 25/12/2024
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: CDK-activating kinase
Fitted models: 8s0t

Deposition Authors: Feng J , Cronin NB , Marineau JJ , Greber BJ
TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network.
Jones T , Feng J , Luyties O , Cozzolino K, Sanford L, Rimel JK, Ebmeier CC , Shelby GS, Watts LP , Rodino J , Rajagopal N, Hu S, Brennan F , Maas ZL , Alnemy S, Richter WF , Koh AF , Cronin NB , Madduri A , Das J, Cooper E, Hamman KB , Carulli JP , Allen MA , Spencer S , Kotecha A , Marineau JJ , Greber BJ , Dowell RD , Taatjes DJ
(2025) Sci Adv , 11 , eadr9660 - eadr9660
PUBMED: 40020069
DOI: doi:10.1126/sciadv.adr9660
ISSN: 2375-2548
Grant Support: