Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-19277
Cryo-EM of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3) (C2)
EMD-19277
Single-particle4.4 Å
Deposition: 25/12/2023Map released: 13/03/2024
Last modified: 27/03/2024
Sample Organism:
Xenopus laevis
Sample: Tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3)
Deposition Authors: Wiseman B
,
Nishio S ,
Jovine L
Sample: Tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3)
Deposition Authors: Wiseman B
,
Nishio S ,
Jovine L
ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat.
Nishio S ,
Emori C,
Wiseman B ,
Fahrenkamp D,
Dioguardi E,
Zamora-Caballero S ,
Bokhove M ,
Han L,
Stsiapanava A,
Algarra B,
Lu Y ,
Kodani M,
Bainbridge RE,
Komondor KM,
Carlson AE,
Landreh M,
de Sanctis D,
Yasumasu S,
Ikawa M ,
Jovine L
(2024) Cell , 187 , 1440 - 1459.e24
,
Emori C,
Wiseman B ,
Fahrenkamp D,
Dioguardi E,
Zamora-Caballero S ,
Bokhove M ,
Han L,
Stsiapanava A,
Algarra B,
Lu Y ,
Kodani M,
Bainbridge RE,
Komondor KM,
Carlson AE,
Landreh M,
de Sanctis D,
Yasumasu S,
Ikawa M ,
Jovine L
(2024) Cell , 187 , 1440 - 1459.e24
Secondary citations:
- Gerton GL & Hedrick JL. (1986) The vitelline envelope to fertilization envelope conversion in eggs of Xenopus laevis. 116, 1 - 7
- Tian J, Gong H, Thomsen GH & Lennarz WJ. (1997) Gamete interactions in Xenopus laevis: identification of sperm binding glycoproteins in the egg vitelline envelope. J Cell Biol, 136, 1099 - 1108
- Tian J, Gong H, Thomsen GH & Lennarz WJ. (1997) Xenopus laevis sperm-egg adhesion is regulated by modifications in the sperm receptor and the egg vitelline envelope. 187, 143 - 153
- Tian J, Gong H & Lennarz WJ. (1999) Xenopus laevis sperm receptor gp69/64 glycoprotein is a homolog of the mammalian sperm receptor ZP2. PNAS, 96, 829 - 834
- Lindsay LL & Hedrick JL. (2004) Proteolysis of Xenopus laevis egg envelope ZPA triggers envelope hardening. 324, 648 - 654
- Scarpeci SL, Sanchez ML & Cabada MO. (2008) Cellular origin of the Bufo arenarum sperm receptor gp75, a ZP2 family member: its proteolysis after fertilization. 100, 219 - 230
- & Hedrick JL. (2008) Anuran and pig egg zona pellucida glycoproteins in fertilization and early development. 52, 683 - 701
Grant Support:
- Swedish Research Council: 2016-03999 (Sweden)
- Swedish Research Council: 2020-04936 (Sweden)
- Knut and Alice Wallenberg Foundation: 2018.0042 (Sweden)