EMD-18999

Single-particle
2.6 Å
EMD-18999
3D View Gallery
Deposition: 29/11/2023
Map released: 13/12/2023
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-18999

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8r8d summary report (pdf.gz) Map-8r8d FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)

EMD-18999

Single-particle
2.6 Å
EMD-18999
3D View Gallery
Deposition: 29/11/2023
Map released: 13/12/2023
Last modified: 13/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of coagulation factor beta-XIIa with garadacimab Fab fragment and anti-LC-lambda VHH
Fitted models: 8r8d

Deposition Authors: Drulyte I
Structural basis for the inhibition of beta FXIIa by garadacimab.
Drulyte I, Ghai R, Ow SY, Kapp EA, Quek AJ, Panousis C, Wilson MJ, Nash AD, Pelzing M
(2024) Structure , 32 , 1705
PUBMED: 39059382
DOI: doi:10.1016/j.str.2024.07.001
ISSN: 0969-2126
ASTM: STRUE6
Grant Support: