EMD-18778

Single-particle
3.1 Å
EMD-18778
3D View Gallery
Deposition: 27/10/2023
Map released: 23/10/2024
Last modified: 18/12/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-18778
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8qzm summary report (pdf.gz) Map and 8qzm FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of DNMT3A1 UDR region bound to H2AK119ub nucleosome

EMD-18778

Single-particle
3.1 Å
EMD-18778
3D View Gallery
Deposition: 27/10/2023
Map released: 23/10/2024
Last modified: 18/12/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: DNMT3A1-DNMT3L in complex with a human H2AKc119ub nucleosome wrapped with 195bp of Widom-601 positioning DNA
Fitted models: 8qzm

Deposition Authors: Wapenaar H , Wilson MD
The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Wapenaar H , Clifford G, Rolls W , Pasquier M, Burdett H, Zhang Y , Deak G, Zou J , Spanos C , Taylor MRD, Mills J , Watson JA , Kumar D, Clark R , Das A, Valsakumar D , Bramham J, Voigt P , Sproul D , Wilson MD
(2024) EMBO Rep , 25 , 5743 - 5779
PUBMED: 39528729
DOI: doi:10.1038/s44319-024-00306-3
ISSN: 1469-3178
Grant Support: