EMD-18299

Single-particle
3.14 Å
EMD-18299
3D View Gallery
Deposition: 22/08/2023
Map released: 08/11/2023
Last modified: 10/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-18299

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8qa5 summary report (pdf.gz) Map-8qa5 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

MTHFR + SAH asymmetric dis-inhibited state

EMD-18299

Single-particle
3.14 Å
EMD-18299
3D View Gallery
Deposition: 22/08/2023
Map released: 08/11/2023
Last modified: 10/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human 5,10-methylenetetrahydrofolate reductase in complex with S-Adenosyl-L-homocysteine, regulatory domains with one catalytic domain
Fitted models: 8qa5

Deposition Authors: Blomgren LKM , Yue WW , Froese DS , McCorvie TJ
Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase.
Blomgren LKM , Huber M, Mackinnon SR , Burer C, Basle A , Yue WW , Froese DS , McCorvie TJ
(2024) Nat Commun , 15 , 3248 - 3248
PUBMED: 38622112
DOI: doi:10.1038/s41467-024-47174-y
ISSN: 2041-1723
Grant Support: