EMD-18009

Single-particle
3.32 Å
EMD-18009
3D View Gallery
Deposition: 24/07/2023
Map released: 05/02/2025
Last modified: 20/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-18009
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8py2 summary report (pdf.gz) Map and 8py2 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2

EMD-18009

Single-particle
3.32 Å
EMD-18009
3D View Gallery
Deposition: 24/07/2023
Map released: 05/02/2025
Last modified: 20/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: BRISC dimer in complex with inhibitor JMS-175-2
Fitted models: 8py2

Deposition Authors: Chandler F , Zeqiraj E
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.
Chandler F , Reddy PAN, Bhutda S, Ross RL, Datta A, Walden M, Walker K , Di Donato S, Cassel JA, Prakesch MA , Aman A , Datti A , Campbell LJ, Foglizzo M , Bell L , Stein DN, Ault JR, Al-Awar RS, Calabrese AN , Sicheri F , Del Galdo F , Salvino JM , Greenberg RA , Zeqiraj E
(2025) Nat Struct Mol Biol
PUBMED: 40097626
DOI: doi:10.1038/s41594-025-01517-5
ISSN: 1545-9985
Grant Support: