EMD-17747
Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex
EMD-17747
Single-particle2.9 Å
Deposition: 27/06/2023Map released: 29/05/2024
Last modified: 02/07/2025
Sample Organism:
Homo sapiens
Sample: befiradol-bound Serotonin 5-HT1A receptor - Gi Protein Complex
Fitted models: 8pkm
Deposition Authors: Schneider J
,
Gmeiner P ,
Hove TT,
Rasmussen T ,
Boettcher B
Sample: befiradol-bound Serotonin 5-HT1A receptor - Gi Protein Complex
Fitted models: 8pkm
Deposition Authors: Schneider J
,
Gmeiner P ,
Hove TT,
Rasmussen T ,
Boettcher B
Discovery of a functionally selective serotonin receptor (5-HT 1A R) agonist for the treatment of pain.
Ullrich A ,
Schneider J ,
Braz JM ,
Neu E ,
Staffen N,
Stanek M,
Blahova J ,
Hove T ,
Albert T,
Allikalt A ,
Lober S,
Bhardwaj K ,
Rodriguez-Rosado S ,
Fink E,
Rasmussen T ,
Hubner H,
Inoue A ,
Shoichet BK ,
Basbaum AI ,
Bottcher B,
Weikert D ,
Gmeiner P
(2025) Sci Adv , 11 , eadv9267 - eadv9267
,
Schneider J ,
Braz JM ,
Neu E ,
Staffen N,
Stanek M,
Blahova J ,
Hove T ,
Albert T,
Allikalt A ,
Lober S,
Bhardwaj K ,
Rodriguez-Rosado S ,
Fink E,
Rasmussen T ,
Hubner H,
Inoue A ,
Shoichet BK ,
Basbaum AI ,
Bottcher B,
Weikert D ,
Gmeiner P
(2025) Sci Adv , 11 , eadv9267 - eadv9267
Grant Support:
- iNEXT-Discovery: 24759 (European Union)
- German Research Foundation (DFG): INST 93/903-1 (Germany)
- German Research Foundation (DFG): INST 93/1042-1 (Germany)