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EMD-17103
Structure of methylamine treated human complement C3
EMD-17103
Single-particle2.9 Å
Deposition: 11/04/2023Map released: 21/02/2024
Last modified: 02/07/2025
Sample Organism:
Homo sapiens,
Lama glama
Sample: methylamine treated complement C3 in complex with a nanobody enabling dimer formation
Fitted models: 8oq3
Deposition Authors: Gadeberg TAF, Andersen GR
Sample: methylamine treated complement C3 in complex with a nanobody enabling dimer formation
Fitted models: 8oq3
Deposition Authors: Gadeberg TAF, Andersen GR
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring.
Gadeberg TAF,
Jorgensen MH ,
Olesen HG,
Lorentzen J ,
Harwood SL,
Almeida AV,
Fruergaard MU,
Jensen RK ,
Kanis P ,
Pedersen H,
Tranchant E ,
Petersen SV,
Thogersen IB,
Kragelund BB ,
Lyons JA ,
Enghild JJ ,
Andersen GR
(2025) Nat Struct Mol Biol
,
Olesen HG,
Lorentzen J ,
Harwood SL,
Almeida AV,
Fruergaard MU,
Jensen RK ,
Kanis P ,
Pedersen H,
Tranchant E ,
Petersen SV,
Thogersen IB,
Kragelund BB ,
Lyons JA ,
Enghild JJ ,
Andersen GR
(2025) Nat Struct Mol Biol
Grant Support:
- Lundbeckfonden: R155-2015-2666 (Denmark)
- Novo Nordisk Foundation: NNF18OC0052105 (Denmark)
- Danish Council for Independent Research: 4181-00137B (Denmark)