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EMD-16534
human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine
EMD-16534
Single-particle3.4 Å
Deposition: 24/01/2023Map released: 11/10/2023
Last modified: 09/07/2025
Sample Organism:
Homo sapiens,
Vicugna pacos
Sample: Complex of the human alpha7 nicotinic acetylcholine receptor withthe Nanobody C4 and with Nicotine
Fitted models: 8cau
Deposition Authors: Prevost MS
,
Barilone N,
Dejean de la Batie G,
Pons S,
Ayme G ,
England P ,
Gielen M ,
Bontems F,
Pehau-Arnaudet G ,
Maskos U ,
Lafaye P,
Corringer P-J
Sample: Complex of the human alpha7 nicotinic acetylcholine receptor withthe Nanobody C4 and with Nicotine
Fitted models: 8cau
Deposition Authors: Prevost MS
,
Barilone N,
Dejean de la Batie G,
Pons S,
Ayme G ,
England P ,
Gielen M ,
Bontems F,
Pehau-Arnaudet G ,
Maskos U ,
Lafaye P,
Corringer P-J
An original potentiating mechanism revealed by the cryo-EM structures of the human alpha 7 nicotinic receptor in complex with nanobodies.
Prevost MS ,
Barilone N,
Dejean de la Batie G,
Pons S,
Ayme G ,
England P ,
Gielen M ,
Bontems F,
Pehau-Arnaudet G ,
Maskos U ,
Lafaye P,
Corringer PJ
(2023) Nat Commun , 14 , 5964 - 5964
,
Barilone N,
Dejean de la Batie G,
Pons S,
Ayme G ,
England P ,
Gielen M ,
Bontems F,
Pehau-Arnaudet G ,
Maskos U ,
Lafaye P,
Corringer PJ
(2023) Nat Commun , 14 , 5964 - 5964
Grant Support:
- European Research Council (ERC): 788974 (European Union)
- Pasteur Institute: (France)
- Centre National de la Recherche Scientifique (CNRS): (France)
- iNEXT-Discovery: (European Union)
- Agence Nationale de la Recherche (ANR): ANR-21-CE37-0026 (France)