Electron Microscopy Data Bank

Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-15587

Single-particle
2.92 Å

3D View Gallery

Deposition: 13/08/2022
Map released: 01/03/2023
Last modified: 15/03/2023

Overview 3D View Sample Experiment Validation Additional data Links

EMD-15587

Download

BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (three up, full)

EMD-15587

Single-particle
2.92 Å
EMD-15587

3D View Gallery

Deposition: 13/08/2022
Map released: 01/03/2023
Last modified: 15/03/2023

Overview 3D View Sample Experiment Validation Additional data Links

Sample Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Sample: BA.4/5 SARS-CoV-2 Spike bound to human ACE2

Deposition Authors: Lau K, Ni D, Beckert B, Nazarov S, Myasnikov A, Pojer F, Stahlberg H, Uchikawa E

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Ni D, Turelli P, Beckert B, Nazarov S, Uchikawa E, Myasnikov A, Pojer F, Trono D, Stahlberg H, Lau K
(2023) PLoS Pathog

DOI: doi:10.1371/journal.ppat.1011206
ISSN: 1553-7374

Secondary citations:

Ni D, Turelli P, Beckert B, Nazarov S, Uchikawa E, Myasnikov A, Pojer F, Trono D, Stahlberg H & Lau K. (2023) Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range. bioRxiv,

Grant Support:

Swiss National Science Foundation: NCCR transcure (Switzerland)