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EMD-15518
human MutSalpha mutant (MSH2-V63E/MSH6) on DNA containing a GT mismatch
EMD-15518
Single-particle4.0 Å
Deposition: 01/08/2022Map released: 25/01/2023
Last modified: 25/01/2023
Sample Organism:
Homo sapiens,
synthetic construct
Sample: human MutSalpha mutant (MSH2-V63E/MSH6) on mismatched DNA
Deposition Authors: Bruekner SR
,
Sixma TK
Sample: human MutSalpha mutant (MSH2-V63E/MSH6) on mismatched DNA
Deposition Authors: Bruekner SR
,
Sixma TK
Unexpected moves: a conformational change in MutSalpha enables high affinity DNA mismatch binding
Bruekner SR ,
Pieters W,
Fish A,
Liaci AM,
Scheffers S,
Rayner E,
Kaldenbach D,
Drost L,
Dekker M,
van Hees-Stuivenberg S,
Delzenne-Goette E,
de Konink C,
Houllleberghs H,
Dubbink HJ,
AlSaegh A,
de Wind N,
Forster F,
te Riele H,
Sixma TK
(2023) Nucleic Acids Res
,
Pieters W,
Fish A,
Liaci AM,
Scheffers S,
Rayner E,
Kaldenbach D,
Drost L,
Dekker M,
van Hees-Stuivenberg S,
Delzenne-Goette E,
de Konink C,
Houllleberghs H,
Dubbink HJ,
AlSaegh A,
de Wind N,
Forster F,
te Riele H,
Sixma TK
(2023) Nucleic Acids Res
ISSN: 1362-4962
ASTM: NARHAD
ASTM: NARHAD
Grant Support:
- Netherlands Organisation for Scientific Research (NWO): NOW-TOP 714.016.002 (Netherlands)
- European Commission: H2020-MSCA-ITN-2016 722433 DNAREPAIRMAN (European Union)