EMD-15025

Single-particle
2.7 Å
EMD-15025
3D View Gallery
Deposition: 24/05/2022
Map released: 28/09/2022
Last modified: 24/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-15025
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7zyj summary report (pdf.gz) Map and 7zyj FULL report (pdf.gz)
EMICSS annotations (xml)

Leishmania tarentolae proteasome 20S subunit in complex with compound 2

EMD-15025

Single-particle
2.7 Å
EMD-15025
3D View Gallery
Deposition: 24/05/2022
Map released: 28/09/2022
Last modified: 24/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Leishmania tarentolae
Sample: Proteasome
Fitted models: 7zyj

Deposition Authors: Srinivas H
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).
Koester DC , Marx VM, Williams S, Jiricek J, Dauphinais M, Rene O, Miller SL, Zhang L, Patra D, Chen YL, Cheung H, Gable J, Lakshminarayana SB, Osborne C, Galarneau JR, Kulkarni U, Richmond W, Bretz A , Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Maser P, Kaiser M , Ritchie R, Barrett MP, Diagana TT, Sarko C, Rao SPS
(2022) J Med Chem , 65 , 11776 - 11787
PUBMED: 35993839
DOI: doi:10.1021/acs.jmedchem.2c00791
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: