Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-14517

Single-particle
4.16 Å
EMD-14517
3D View Gallery
Deposition: 09/03/2022
Map released: 11/05/2022
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-14517
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 7z5c summary report (pdf.gz) Map and 7z5c FULL report (pdf.gz)
EMICSS annotations (xml)

Chimaera of AP2 with FCHO2 linker domain as a fusion on Cmu2 subunit

EMD-14517

Single-particle
4.16 Å
EMD-14517
3D View Gallery
Deposition: 09/03/2022
Map released: 11/05/2022
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Rattus norvegicus, Escherichia coli 'BL21-Gold(DE3)pLysS AG', Homo sapiens, Mus musculus
Sample: AP2 core complex
Fitted models: 7z5c

Deposition Authors: Kane Dickson V, Qu K , Owen DJ , Briggs JA , Zaccai NR
FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Zaccai NR , Kadlecova Z , Dickson VK , Korobchevskaya K, Kamenicky J, Kovtun O , Umasankar PK , Wrobel AG , Kaufman JGG , Gray SR , Qu K , Evans PR, Fritzsche M , Sroubek F , Honing S, Briggs JAG, Kelly BT , Owen DJ , Traub LM
(2022) Sci Adv , 8 , eabn2018 - eabn2018
PUBMED: 35486718
DOI: doi:10.1126/sciadv.abn2018
ISSN: 2375-2548
Grant Support: