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EMD-13841
Focused refinement of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA
EMD-13841
Single-particle2.69 Å
Deposition: 03/11/2021Map released: 19/01/2022
Last modified: 19/01/2022
Sample Organism:
Escherichia coli K-12,
Homo sapiens
Sample: Hedgehog acyltransferase (HHAT) bound to non hydrolysable palmitoyl-CoA in complex with megabody 177
Deposition Authors: Coupland C, Carrique L
,
Siebold C
Sample: Hedgehog acyltransferase (HHAT) bound to non hydrolysable palmitoyl-CoA in complex with megabody 177
Deposition Authors: Coupland C, Carrique L
,
Siebold C
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE ,
Andrei SA ,
Ansell TB ,
Carrique L ,
Kumar P,
Sefer L,
Schwab RA,
Byrne EFX ,
Pardon E ,
Steyaert J ,
Magee AI,
Lanyon-Hogg T,
Sansom MSP,
Tate EW,
Siebold C
(2021) Mol. Cell , 81 , 5025 - 5038.e10
,
Andrei SA ,
Ansell TB ,
Carrique L ,
Kumar P,
Sefer L,
Schwab RA,
Byrne EFX ,
Pardon E ,
Steyaert J ,
Magee AI,
Lanyon-Hogg T,
Sansom MSP,
Tate EW,
Siebold C
(2021) Mol. Cell , 81 , 5025 - 5038.e10
Grant Support:
- Cancer Research UK: C20724/A26752 (European Union)
- Cancer Research UK: C20724/A14414 (European Union)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/T01508X/1 (European Union)
- European Research Council (ERC): 647278 (European Union)