EMD-13141

Single-particle
2.87 Å
EMD-13141
3D View Gallery
Deposition: 29/06/2021
Map released: 15/12/2021
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-13141

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7p02 summary report (pdf.gz) Map-7p02 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Human Neurokinin 1 receptor (NK1R) substance P Gs complex

EMD-13141

Single-particle
2.87 Å
EMD-13141
3D View Gallery
Deposition: 29/06/2021
Map released: 15/12/2021
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: NK1R in complex with Substance P, heterotrimeric mini-Gs chimera (Gsi) and scFv16
Fitted models: 7p02

Deposition Authors: Thom C , Ehrenmann J
Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.
Thom C , Ehrenmann J , Vacca S , Waltenspuhl Y , Schoppe J , Medalia O , Pluckthun A
(2021) Sci Adv , 7 , eabk2872 - eabk2872
PUBMED: 34878828
DOI: doi:10.1126/sciadv.abk2872
ISSN: 2375-2548