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EMD-0282

Single-particle
3.26 Å
EMD-0282
3D View Gallery
Deposition: 09/10/2018
Map released: 02/01/2019
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-0282
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 6huo summary report (pdf.gz) Map and 6huo FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38.

EMD-0282

Single-particle
3.26 Å
EMD-0282
3D View Gallery
Deposition: 09/10/2018
Map released: 02/01/2019
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38.
Fitted models: 6huo

Deposition Authors: Masiulis S, Desai R
GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Masiulis S, Desai R, Uchanski T , Serna Martin I , Laverty D, Karia D, Malinauskas T , Zivanov J, Pardon E , Kotecha A , Steyaert J , Miller KW, Aricescu AR
(2019) Nature , 565 , 454 - 459
PUBMED: 30602790
DOI: doi:10.1038/s41586-018-0832-5
ISSN: 0028-0836
ASTM: NATUAS