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sample_name:"Polycomb Repressive Complex 2"

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Current Database

  • EMDB [24]

Current status

  • REL [24]

Sample type

  • Complex [23]
  • Protein [9]
  • RNA [3]
  • Ligand [2]
  • Sample [1]

Organism

  • Homo sapiens [24]

EM Method

  • Single-particle [24]

Resolution

  • ≥ 3Å and < 4Å [14]
  • ≥ 4Å and < 5Å [4]
  • ≥ 6Å and < 8Å [2]
  • ≥ 8Å and < 12Å [2]
  • ≥ 12Å and < 16Å [1]
  • ≥ 20Å and < 30Å [1]

Model molecular weight

  • 500-1000 kDa [2]

Release Date

  • 2026 [4]
  • 2025 [3]
  • 2024 [7]
  • 2023 [3]
  • 2018 [6]
  • 2012 [1]

Author by name

  • Kasinath V [16]
  • Abe KM [7]
  • Grant T [7]
  • Li G [7]
  • Lim CJ [7]
  • Nogales E [7]
  • Cech TR [6]
  • Gooding AR [6]
  • He Q [6]
  • Hemphill WO [6]
  • Poepsel S [6]
  • Song J [6]
  • Yao L [6]
  • Garcia BA [4]
  • Hazzard R [4]
  • Jiarui JS [4]
  • Lewis PW [4]
  • Matyas M [4]
  • Matyas MN [4]
  • Porter EG [4]
  • Rashoff AQ [4]
  • Vignesh VK [4]
  • Goodrich K [3]
  • Love BD [3]
  • North TE [3]
  • Robertson A [3]
  • Thron V [3]
  • Zon LI [3]
  • Aebersold R [1]
  • Ciferri C [1]
  • Herzog F [1]
  • Kasinath VK [1]
  • Lander GC [1]
  • Lim C [1]
  • Maiolica A [1]
  • Song JS [1]

Author by ORCID

  • Kasinath V [10]
  • Abe KM [7]
  • Grant T [7]
  • Lim CJ [7]
  • Cech TR [6]
  • Nogales E [6]
  • He Q [6]
  • Hemphill WO [6]
  • Poepsel S [6]
  • Song J [6]
  • Garcia BA [4]
  • Rashoff AQ [4]
  • Lewis PW [4]
  • Porter EG [4]
  • Hazzard R [4]
  • Matyas M [4]
  • Yao L [3]
  • Love BD [3]
  • Gooding AR [3]
  • Zon LI [3]
  • Herzog F [1]
  • Lander GC [1]
  • Li G [1]

Journal

  • BIORXIV [7]
  • NAT COMMUN [6]
  • NAT STRUCT MOL BIOL [6]
  • SCIENCE [3]
  • ELIFE [1]
  • TO BE PUBLISHED [1]

Software

  • CRYOSPARC [11]
  • RELION [6]
  • APPION, LEGINON, SPIDER, IMAGIC, EMAN2, SPARX [1]
  • CHIMERA [1]

Microscope

  • FEI TALOS ARCTICA [7]
  • FEI TITAN KRIOS [6]
  • FEI TITAN [5]
  • TFS KRIOS [4]
  • FEI TECNAI 20 [2]

Electron Source

  • FIELD EMISSION GUN [24]

Film or detector model

  • GATAN K3 BIOQUANTUM 6K X 4K [7]
  • FEI FALCON IV 4K X 4K [6]
  • GATAN K2 SUMMIT 4K X 4K [5]
  • GATAN K3 6K X 4K [4]
  • GATAN ULTRASCAN 4000 4K X 4K [1]
  • GENERIC GATAN 4K X 4K [1]

External links

  • PDB [24]
  • AlphaFold DB [6]
  • Complex Portal [6]
  • EMPIAR [6]
  • PDBe-Kb [6]
  • UniProt [6]
  • ChEBI [2]
  • ChEMBL [2]
  • DrugBank [2]
  • Gene Ontology [2]
  • InterPro [2]
  • Pfam [2]
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Showing 1 - 10 of 24. Page 1 of 3
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EMD-76889
Download Map
3D View
PRC2 EZH2 S21A AJ106-350 in the compact active state
CryoEM
Release date: July 1, 2026
Resolution: 3.4 Å
EM Method: Single-particle

Rashoff AQ, Matyas M, Porter EG, Hazzard R, Garcia BA, Kasinath V, Lewis PW

bioRxiv (2026) [ DOI: doi:10.64898/2026.06.02.729660 Pubmed: 42282706 ]

EMD-76893
Download Map
3D View
PRC2 EZH2 S21A AJ106-350 in the extended active state
CryoEM
Release date: July 1, 2026
Resolution: 3.9 Å
EM Method: Single-particle

Rashoff AQ, Matyas M, Porter EG, Hazzard R, Garcia BA, Kasinath V, Lewis PW

bioRxiv (2026) [ DOI: doi:10.64898/2026.06.02.729660 Pubmed: 42282706 ]

EMD-76902
Download Map
3D View
PRC2 EZH2 WT AJ106-350 in the compact active state
CryoEM
Release date: July 1, 2026
Resolution: 4.2 Å
EM Method: Single-particle

Rashoff AQ, Matyas M, Porter EG, Hazzard R, Garcia BA, Kasinath V, Lewis PW

bioRxiv (2026) [ DOI: doi:10.64898/2026.06.02.729660 Pubmed: 42282706 ]

EMD-76903
Download Map
3D View
PRC2 EZH2 WT AJ106-350 in the extended active state
CryoEM
Release date: July 1, 2026
Resolution: 3.7 Å
EM Method: Single-particle

Rashoff AQ, Matyas M, Porter EG, Hazzard R, Garcia BA, Kasinath V, Lewis PW

bioRxiv (2026) [ DOI: doi:10.64898/2026.06.02.729660 Pubmed: 42282706 ]

EMD-46722
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3D View
Body 1 from multibody refinement of the single-stranded TERRAmut RNA-bound PRC2 dimer
Focused map
CryoEM
Release date: March 12, 2025
Resolution: 3.3 Å
EM Method: Single-particle

Song J, Yao L, Gooding AR, Thron V, Hemphill WO, Goodrich K, Kasinath V, Cech TR

bioRxiv (2025) [ Pubmed: 39257770 DOI: doi:10.1101/2024.08.29.610323 ]

EMD-46726
Download Map
3D View
Body 2 from multibody refinement of the single-stranded TERRAmut RNA-bound PRC2 dimer
Composite map
CryoEM
Release date: March 12, 2025
Resolution: 3.4 Å
EM Method: Single-particle

Song J, Yao L, Gooding AR, Thron V, Hemphill WO, Goodrich K, Kasinath V, Cech TR

bioRxiv (2025) [ Pubmed: 39257770 DOI: doi:10.1101/2024.08.29.610323 ]

EMD-46751
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3D View
Single-stranded RNA-mediated PRC2 dimer
CryoEM
Release date: March 12, 2025
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9dch
Q-score: 0.267
Similar entry percentile: 5%

Song J, Yao L, Gooding AR, Thron V, Hemphill WO, Goodrich K, Kasinath V, Cech TR

bioRxiv (2025) [ Pubmed: 39257770 DOI: doi:10.1101/2024.08.29.610323 ]

EMD-43623
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3D View
Human PRC2 - AavLEA1 1:12 molar ratio
CryoEM
Release date: Dec. 18, 2024
Resolution: 3.62 Å
EM Method: Single-particle

Abe KM, Li G, He Q, Grant T, Lim CJ

Nat Commun (2024) 15 pp. 7705-7705 [ Pubmed: 39231985 DOI: doi:10.1038/s41467-024-52091-1 ]

EMD-43620
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3D View
Raw data
EMPIAR-11975
Human PRC2 - AavLEA1 1:40 molar ratio
CryoEM
Release date: Sept. 4, 2024
Resolution: 3.82 Å
EM Method: Single-particle

Abe KM, Li G, He Q, Grant T, Lim CJ

Nat Commun (2024) 15 pp. 7705-7705 [ Pubmed: 39231985 DOI: doi:10.1038/s41467-024-52091-1 ]

EMD-43621
Download Map
3D View
Raw data
EMPIAR-11976
Human PRC2 - RvLEAM short 1:6 molar ratio
CryoEM
Release date: Sept. 4, 2024
Resolution: 3.76 Å
EM Method: Single-particle

Abe KM, Li G, He Q, Grant T, Lim CJ

Nat Commun (2024) 15 pp. 7705-7705 [ Pubmed: 39231985 DOI: doi:10.1038/s41467-024-52091-1 ]

Sort by: Download
Showing 1 - 10 of 24. Page 1 of 3
Display:
Statistics
×

Download


Preview 10 entries View All Download file

Filter By

Current Database

  • EMDB [24]

Current status

  • REL [24]

Sample type

  • Complex [23]
  • Protein [9]
  • RNA [3]
  • Ligand [2]
  • Sample [1]

Organism

  • Homo sapiens [24]

EM Method

  • Single-particle [24]

Resolution

  • ≥ 3Å and < 4Å [14]
  • ≥ 4Å and < 5Å [4]
  • ≥ 6Å and < 8Å [2]
  • ≥ 8Å and < 12Å [2]
  • ≥ 12Å and < 16Å [1]
  • ≥ 20Å and < 30Å [1]

Model molecular weight

  • 500-1000 kDa [2]

Release Date

  • 2026 [4]
  • 2025 [3]
  • 2024 [7]
  • 2023 [3]
  • 2018 [6]
  • 2012 [1]

Author by name

  • Kasinath V [16]
  • Abe KM [7]
  • Grant T [7]
  • Li G [7]
  • Lim CJ [7]
  • Nogales E [7]
  • Cech TR [6]
  • Gooding AR [6]
  • He Q [6]
  • Hemphill WO [6]
  • Poepsel S [6]
  • Song J [6]
  • Yao L [6]
  • Garcia BA [4]
  • Hazzard R [4]
  • Jiarui JS [4]
  • Lewis PW [4]
  • Matyas M [4]
  • Matyas MN [4]
  • Porter EG [4]
  • Rashoff AQ [4]
  • Vignesh VK [4]
  • Goodrich K [3]
  • Love BD [3]
  • North TE [3]
  • Robertson A [3]
  • Thron V [3]
  • Zon LI [3]
  • Aebersold R [1]
  • Ciferri C [1]
  • Herzog F [1]
  • Kasinath VK [1]
  • Lander GC [1]
  • Lim C [1]
  • Maiolica A [1]
  • Song JS [1]

Author by ORCID

  • Kasinath V [10]
  • Abe KM [7]
  • Grant T [7]
  • Lim CJ [7]
  • Cech TR [6]
  • Nogales E [6]
  • He Q [6]
  • Hemphill WO [6]
  • Poepsel S [6]
  • Song J [6]
  • Garcia BA [4]
  • Rashoff AQ [4]
  • Lewis PW [4]
  • Porter EG [4]
  • Hazzard R [4]
  • Matyas M [4]
  • Yao L [3]
  • Love BD [3]
  • Gooding AR [3]
  • Zon LI [3]
  • Herzog F [1]
  • Lander GC [1]
  • Li G [1]

Journal

  • BIORXIV [7]
  • NAT COMMUN [6]
  • NAT STRUCT MOL BIOL [6]
  • SCIENCE [3]
  • ELIFE [1]
  • TO BE PUBLISHED [1]

Software

  • CRYOSPARC [11]
  • RELION [6]
  • APPION, LEGINON, SPIDER, IMAGIC, EMAN2, SPARX [1]
  • CHIMERA [1]

Microscope

  • FEI TALOS ARCTICA [7]
  • FEI TITAN KRIOS [6]
  • FEI TITAN [5]
  • TFS KRIOS [4]
  • FEI TECNAI 20 [2]

Electron Source

  • FIELD EMISSION GUN [24]

Film or detector model

  • GATAN K3 BIOQUANTUM 6K X 4K [7]
  • FEI FALCON IV 4K X 4K [6]
  • GATAN K2 SUMMIT 4K X 4K [5]
  • GATAN K3 6K X 4K [4]
  • GATAN ULTRASCAN 4000 4K X 4K [1]
  • GENERIC GATAN 4K X 4K [1]

External links

  • PDB [24]
  • AlphaFold DB [6]
  • Complex Portal [6]
  • EMPIAR [6]
  • PDBe-Kb [6]
  • UniProt [6]
  • ChEBI [2]
  • ChEMBL [2]
  • DrugBank [2]
  • Gene Ontology [2]
  • InterPro [2]
  • Pfam [2]