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sample_name:"Isocitrate dehydrogenase R132C mutant in complex with ML309"

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EMD-8193
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Cryo-EM structure of isocitrate dehydrogenase IDH1 in complex with ML309 inhibitor
Release date: June 8, 2016
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5k11
Q-score: 0.331

Merk A, Bartesaghi A, Banerjee S, Falconieri V, Rao P, Davis MI, Pragani R, Boxer MB, Earl LA, Milne JL, Subramaniam S

Cell (2016) 165 pp. 1698-1707 [ Pubmed: 27238019 DOI: doi:10.1016/j.cell.2016.05.040 ]

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Filter By

Current Database

  • EMDB [1]

Current status

  • REL [1]

Sample type

  • Complex [1]
  • Ligand [1]
  • Protein [1]

Organism

  • Homo sapiens [1]

EM Method

  • Single-particle [1]

Resolution

  • ≥ 3Å and < 4Å [1]

Model molecular weight

  • 50-100 kDa [1]

Release Date

  • 2016 [1]

Author by name

  • Banerjee S [1]
  • Bartesaghi A [1]
  • Boxer MB [1]
  • Davis MI [1]
  • Earl LA [1]
  • Falconieri V [1]
  • Merk A [1]
  • Milne JL [1]
  • Pragani R [1]
  • Rao P [1]
  • Subramaniam S [1]

Author by ORCID

  • Davis MI [1]
  • Subramaniam S [1]

Journal

  • CELL [1]

Software

  • FREALIGN [1]

Microscope

  • FEI TITAN KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [1]

Film or detector model

  • GATAN K2 QUANTUM 4K X 4K [1]

External links

  • AlphaFold DB [1]
  • CATH [1]
  • ChEBI [1]
  • ChEMBL [1]
  • Complex Portal [1]
  • DrugBank [1]
  • Gene Ontology [1]
  • InterPro [1]
  • PDB [1]
  • PDBe-Kb [1]
  • Pfam [1]
  • UniProt [1]