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EMD-38243
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SARS-CoV-2 Replication-Transcription Complex has a dimer-of-dimeric architecture ddRTC in pre-capping initiation.
CryoEM
Release date: June 11, 2025
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xch

Yan L, Huang Y, Liu Y, Ge J, Gao S, Tan L, Liu L, Liu Z, Ye S, Wang J, Xiong J, Zhou Y, Zhao H, Zhao X, Guddat LW, Gao Y, Zhu L, Rao Z, Lou Z

Cell (2025) [ Pubmed: 41130208 DOI: doi:10.1016/j.cell.2025.09.022 ]

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Filter By

Current Database

  • EMDB [1]

Current status

  • REL [1]

Sample type

  • Complex [1]
  • Ligand [1]
  • Protein [1]
  • RNA [1]

Organism

  • Severe acute respiratory syndrome coronavirus [1]
  • Synthetic construct [1]

EM Method

  • Single-particle [1]

Resolution

  • ≥ 3Å and < 4Å [1]

Model molecular weight

  • 1-2 MDa [1]

Release Date

  • 2025 [1]

Author by name

  • Gao S [1]
  • Gao Y [1]
  • Ge J [1]
  • Guddat LW [1]
  • Huang Y [1]
  • Liu L [1]
  • Liu Y [1]
  • Liu Z [1]
  • Lou Z [1]
  • Rao Z [1]
  • Tan L [1]
  • Wang J [1]
  • Xiong J [1]
  • Yan L [1]
  • Ye S [1]
  • Zhao H [1]
  • Zhao X [1]
  • Zhou Y [1]
  • Zhu L [1]

Journal

  • CELL [1]

Microscope

  • TFS KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [1]

Film or detector model

  • GATAN K2 QUANTUM 4K X 4K [1]

External links

  • AlphaFold DB [1]
  • ChEBI [1]
  • ChEMBL [1]
  • Complex Portal [1]
  • DrugBank [1]
  • Gene Ontology [1]
  • InterPro [1]
  • PDB [1]
  • PDBe-Kb [1]
  • Pfam [1]
  • UniProt [1]