Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

Edit your search query here and hit Return to execute it:
natural_source_ncbi_code:"1836"

Filter By

Current Database

  • EMDB [12]

Current status

  • REL [12]

Sample type

  • Complex [12]
  • Protein [12]
  • Ligand [2]

Organism

  • Saccharopolyspora erythraea [12]
  • Homo sapiens [10]

EM Method

  • Single-particle [12]

Resolution

  • ≥ 3Å and < 4Å [9]
  • ≥ 4Å and < 5Å [3]

Model molecular weight

  • 100-250 kDa [2]
  • 250-500 kDa [8]
  • 500-1000 kDa [2]

Release Date

  • 2024 [6]
  • 2021 [6]

Author by name

  • Cogan DP [12]
  • Khosla C [12]
  • Brodsky KL [6]
  • Chen M [6]
  • Chiu W [6]
  • Craik CS [6]
  • Li S [6]
  • Li X [6]
  • Liu Y [6]
  • Pintilie GD [6]
  • Roh SH [6]
  • Soohoo AM [6]
  • Zhang K [6]

Author by ORCID

  • Khosla C [12]
  • Cogan DP [12]
  • Liu Y [6]
  • Craik CS [6]
  • Pintilie GD [6]
  • Li X [6]
  • Li S [6]
  • Chiu W [6]
  • Zhang K [6]
  • Chen M [6]
  • Roh SH [6]
  • Soohoo AM [6]

Journal

  • NAT CHEM BIOL [6]
  • SCIENCE [6]

Software

  • CRYOSPARC [6]
  • CTFFIND [2]
  • RELION [1]

Microscope

  • FEI TITAN KRIOS [12]

Electron Source

  • FIELD EMISSION GUN [12]

Film or detector model

  • FEI FALCON IV 4K X 4K [7]
  • GATAN K3 BIOQUANTUM 6K X 4K [5]

External links

  • PDB [12]
  • UniProt [12]
  • PDBe-Kb [11]
  • AlphaFold DB [9]
  • Gene Ontology [8]
  • InterPro [8]
  • Pfam [8]
Sort by: Download
Showing 1 - 10 of 12. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download
EMD-41495
Download Map
3D View
Crosslinked 6-deoxyerythronolide B synthase DEBS Module 3 in complex with antibody fragment 1B2: cis-oriented 1B2 and ACP
Release date: Aug. 7, 2024
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8tpw
Q-score: 0.423

Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C

Nat Chem Biol (2025) 21 pp. 876-882 [ DOI: doi:10.1038/s41589-024-01709-y Pubmed: 39179672 ]

EMD-41496
Download Map
3D View
Crosslinked 6-deoxyerythronolide B synthase DEBS Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP
Release date: Aug. 7, 2024
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tpx
Q-score: 0.396

Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C

Nat Chem Biol (2025) 21 pp. 876-882 [ DOI: doi:10.1038/s41589-024-01709-y Pubmed: 39179672 ]

EMD-41355
Download Map
3D View
KS-AT core of 6-deoxyerythronolide B synthase DEBS Module 3 crosslinked with its translocation ACP partner of Module 2
Release date: July 31, 2024
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8tko
Q-score: 0.493

Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C

Nat Chem Biol (2025) 21 pp. 876-882 [ DOI: doi:10.1038/s41589-024-01709-y Pubmed: 39179672 ]

EMD-41305
Download Map
3D View
Crosslinked 6-deoxyerythronolide B synthase DEBS Module 1 in complex with antibody fragment 1B2: Crosslinked State 1
Release date: July 24, 2024
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8tjn
Q-score: 0.364

Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C

Nat Chem Biol (2025) 21 pp. 876-882 [ DOI: doi:10.1038/s41589-024-01709-y Pubmed: 39179672 ]

EMD-41306
Download Map
3D View
Crosslinked 6-deoxyerythronolide B synthase DEBS Module 1 in complex with antibody fragment 1B2: Crosslinked Intra-State 1
Release date: July 24, 2024
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8tjo
Q-score: 0.365

Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C

Nat Chem Biol (2025) 21 pp. 876-882 [ DOI: doi:10.1038/s41589-024-01709-y Pubmed: 39179672 ]

EMD-41307
Download Map
3D View
KS-AT core of 6-deoxyerythronolide B synthase DEBS Module 3 crosslinked with its elongation ACP partner
Release date: July 24, 2024
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8tjp
Q-score: 0.388

Cogan DP, Soohoo AM, Chen M, Liu Y, Brodsky KL, Khosla C

Nat Chem Biol (2025) 21 pp. 876-882 [ DOI: doi:10.1038/s41589-024-01709-y Pubmed: 39179672 ]

EMD-23710
Download Map
3D View
6-Deoxyerythronolide B synthase DEBS hybrid module M3/1 in complex with antibody fragment 1B2
Release date: Nov. 17, 2021
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7m7e
Q-score: 0.449

Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C

Science (2021) 374 pp. 729-734 [ DOI: doi:10.1126/science.abi8358 Pubmed: 34735239 ]

EMD-23711
Download Map
3D View
6-Deoxyerythronolide B synthase DEBS module 1 in complex with antibody fragment 1B2: State 1
Release date: Nov. 17, 2021
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7m7f
Q-score: 0.403

Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C

Science (2021) 374 pp. 729-734 [ DOI: doi:10.1126/science.abi8358 Pubmed: 34735239 ]

EMD-23712
Download Map
3D View
6-Deoxyerythronolide B synthase DEBS module 1 in complex with antibody fragment 1B2: State 2
Release date: Nov. 17, 2021
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7m7g
Q-score: 0.181

Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C

Science (2021) 374 pp. 729-734 [ DOI: doi:10.1126/science.abi8358 Pubmed: 34735239 ]

EMD-23713
Download Map
3D View
6-Deoxyerythronolide B synthase DEBS module 1 in complex with antibody fragment 1B2: State 1
Release date: Nov. 17, 2021
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7m7h
Q-score: 0.19

Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C

Science (2021) 374 pp. 729-734 [ DOI: doi:10.1126/science.abi8358 Pubmed: 34735239 ]

Sort by: Download
Showing 1 - 10 of 12. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [12]

Current status

  • REL [12]

Sample type

  • Complex [12]
  • Protein [12]
  • Ligand [2]

Organism

  • Saccharopolyspora erythraea [12]
  • Homo sapiens [10]

EM Method

  • Single-particle [12]

Resolution

  • ≥ 3Å and < 4Å [9]
  • ≥ 4Å and < 5Å [3]

Model molecular weight

  • 100-250 kDa [2]
  • 250-500 kDa [8]
  • 500-1000 kDa [2]

Release Date

  • 2024 [6]
  • 2021 [6]

Author by name

  • Cogan DP [12]
  • Khosla C [12]
  • Brodsky KL [6]
  • Chen M [6]
  • Chiu W [6]
  • Craik CS [6]
  • Li S [6]
  • Li X [6]
  • Liu Y [6]
  • Pintilie GD [6]
  • Roh SH [6]
  • Soohoo AM [6]
  • Zhang K [6]

Author by ORCID

  • Khosla C [12]
  • Cogan DP [12]
  • Liu Y [6]
  • Craik CS [6]
  • Pintilie GD [6]
  • Li X [6]
  • Li S [6]
  • Chiu W [6]
  • Zhang K [6]
  • Chen M [6]
  • Roh SH [6]
  • Soohoo AM [6]

Journal

  • NAT CHEM BIOL [6]
  • SCIENCE [6]

Software

  • CRYOSPARC [6]
  • CTFFIND [2]
  • RELION [1]

Microscope

  • FEI TITAN KRIOS [12]

Electron Source

  • FIELD EMISSION GUN [12]

Film or detector model

  • FEI FALCON IV 4K X 4K [7]
  • GATAN K3 BIOQUANTUM 6K X 4K [5]

External links

  • PDB [12]
  • UniProt [12]
  • PDBe-Kb [11]
  • AlphaFold DB [9]
  • Gene Ontology [8]
  • InterPro [8]
  • Pfam [8]