EMD-9895
Structure of human T cell receptor-CD3 complex
EMD-9895
Single-particle3.7 Å
Deposition: 24/04/2019Map released: 11/09/2019
Last modified: 25/06/2025
Name: complex
Summary:
- Complex
- Protein
- T-cell surface glycoprotein CD3 zeta chain
- T-cell surface glycoprotein CD3 delta chain
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD3 gamma chain
- T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha constant
- T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2
Name: complex
Natural source [1]
Organism: Homo sapiens
Complex Portal [2]
| ID | Name | Overlap |
|---|---|---|
| CPX-6482 | Alpha-beta T cell receptor complex, TRBC2 variant | 0.71 |
| CPX-6581 | Alpha-beta T cell receptor complex, TRBC1 variant | 0.71 |
Name: T-cell surface glycoprotein CD3 zeta chain
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Biological process:
cell surface receptor signaling pathway
Molecular function:
transmembrane signaling receptor activity
cell surface receptor signaling pathway
Molecular function:
transmembrane signaling receptor activity
Natural source
Organism: Homo sapiens
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 18 kDa | - |
Recombinant Expression
| Organism | Strain | Cell | Plasmid |
|---|---|---|---|
| Homo sapiens | - | - | - |
Name: T-cell surface glycoprotein CD3 delta chain
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Biological process:
cell surface receptor signaling pathway
Molecular function:
transmembrane signaling receptor activity
cell surface receptor signaling pathway
Molecular function:
transmembrane signaling receptor activity
Natural source
Organism: Homo sapiens
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 18 kDa | - |
Recombinant Expression
| Organism | Strain | Cell | Plasmid |
|---|---|---|---|
| Homo sapiens | - | - | - |
Name: T-cell surface glycoprotein CD3 epsilon chain
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Biological process:
cell surface receptor signaling pathway
Molecular function:
transmembrane signaling receptor activity
cell surface receptor signaling pathway
Molecular function:
transmembrane signaling receptor activity
Natural source
Organism: Homo sapiens
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 23 kDa | - |
Recombinant Expression
| Organism | Strain | Cell | Plasmid |
|---|---|---|---|
| Homo sapiens | - | - | - |
Name: T-cell surface glycoprotein CD3 gamma chain
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [2]
Biological process:
cell surface receptor signaling pathway
Molecular function:
transmembrane signaling receptor activity
cell surface receptor signaling pathway
Molecular function:
transmembrane signaling receptor activity
Natural source
Organism: Homo sapiens
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 20 kDa | - |
Recombinant Expression
| Organism | Strain | Cell | Plasmid |
|---|---|---|---|
| Homo sapiens | - | - | - |
Name: T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha constant
Number of copies: 1
Details: Fusion protein of residues 22-114 from A0A0B4J271, residues 116-132 from A0N4Z6 and residues 134-273 from P01848.
UniProtKB PDBe-KB AlphaFold DB
Number of copies: 1
Details: Fusion protein of residues 22-114 from A0A0B4J271, residues 116-132 from A0N4Z6 and residues 134-273 from P01848.
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [6]
Biological process:
adaptive immune response T cell receptor signaling pathway alpha-beta T cell activation response to bacterium
Cellular location:
alpha-beta T cell receptor complex plasma membrane
adaptive immune response T cell receptor signaling pathway alpha-beta T cell activation response to bacterium
Cellular location:
alpha-beta T cell receptor complex plasma membrane
Natural source
Organism: Homo sapiens
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 28 kDa | - |
Recombinant Expression
| Organism | Strain | Cell | Plasmid |
|---|---|---|---|
| Homo sapiens | - | - | - |
Name: T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2
Number of copies: 1
Details: Fusion protein of residues 22-112 from A0A0K0K1A5, residues 121-134 from P0DSE2 and residues 135-312 from A0A0G2JMB4.
UniProtKB PDBe-KB
Number of copies: 1
Details: Fusion protein of residues 22-112 from A0A0K0K1A5, residues 121-134 from P0DSE2 and residues 135-312 from A0A0G2JMB4.
UniProtKB PDBe-KB
Natural source
Organism: Homo sapiens
Molecular weight
| Experimental | Theoretical | Method |
|---|---|---|
| - | 32 kDa | - |
Recombinant Expression
| Organism | Strain | Cell | Plasmid |
|---|---|---|---|
| Homo sapiens | - | - | - |
