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EMD-9189
Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122
EMD-9189
Single-particle3.8 Å
Deposition: 06/10/2018Map released: 24/07/2019
Last modified: 23/10/2024
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1,
Macaca mulatta
Sample: DF1W-a.01 Fab bound to HIV-1 Env BG505 DS-SOSIP-VRC03 Fab- PGT122 Fab
Fitted models: 6mph
Deposition Authors: Acharya P
,
Xu K
Sample: DF1W-a.01 Fab bound to HIV-1 Env BG505 DS-SOSIP-VRC03 Fab- PGT122 Fab
Fitted models: 6mph
Deposition Authors: Acharya P
,
Xu K
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Kong R,
Duan H ,
Sheng Z,
Xu K,
Acharya P ,
Chen X,
Cheng C,
Dingens AS,
Gorman J ,
Sastry M,
Shen CH,
Zhang B,
Zhou T,
Chuang GY,
Chao CW,
Gu Y,
Jafari AJ,
Louder MK,
O'Dell S,
Rowshan AP,
Viox EG,
Wang Y,
Choi CW,
Corcoran MM ,
Corrigan AR ,
Dandey VP,
Eng ET ,
Geng H,
Foulds KE,
Guo Y ,
Kwon YD,
Lin B,
Liu K,
Mason RD,
Nason MC,
Ohr TY,
Ou L,
Rawi R,
Sarfo EK ,
Schon A,
Todd JP,
Wang S,
Wei H,
Wu W,
Mullikin JC,
Bailer RT,
Doria-Rose NA,
Karlsson Hedestam GB,
Scorpio DG,
Overbaugh J,
Bloom JD,
Carragher B,
Potter CS,
Shapiro L,
Kwong PD ,
Mascola JR
(2019) Cell , 178 , 567 - 584.e19
,
Sheng Z,
Xu K,
Acharya P ,
Chen X,
Cheng C,
Dingens AS,
Gorman J ,
Sastry M,
Shen CH,
Zhang B,
Zhou T,
Chuang GY,
Chao CW,
Gu Y,
Jafari AJ,
Louder MK,
O'Dell S,
Rowshan AP,
Viox EG,
Wang Y,
Choi CW,
Corcoran MM ,
Corrigan AR ,
Dandey VP,
Eng ET ,
Geng H,
Foulds KE,
Guo Y ,
Kwon YD,
Lin B,
Liu K,
Mason RD,
Nason MC,
Ohr TY,
Ou L,
Rawi R,
Sarfo EK ,
Schon A,
Todd JP,
Wang S,
Wei H,
Wu W,
Mullikin JC,
Bailer RT,
Doria-Rose NA,
Karlsson Hedestam GB,
Scorpio DG,
Overbaugh J,
Bloom JD,
Carragher B,
Potter CS,
Shapiro L,
Kwong PD ,
Mascola JR
(2019) Cell , 178 , 567 - 584.e19