EMD-77944
Cryo-EM structure of SLC6A19-ACE2 complex with Compound 6
EMD-77944
Single-particle2.95 Å
Deposition: 05/07/2026Map released: 11/11/2026
Last modified: 11/11/2026
Sample Organism:
Homo sapiens
Sample: SLC6A19-ACE2 complex with Compound 6
Fitted models: 36xh
Deposition Authors: Wasilko DJ, Johnson ZL, Wu H
Sample: SLC6A19-ACE2 complex with Compound 6
Fitted models: 36xh
Deposition Authors: Wasilko DJ, Johnson ZL, Wu H
Structure-Guided Discovery of Orally Bioavailable Allosteric SLC6A19 Inhibitors that Promote Urinary Amino Acid Excretion In Vivo
Wang T,
Dowling MS,
Zhou D,
Wasilko DJ,
Tu M,
Feliers D,
Bernardo B,
Tillotson J,
Ma W,
Brown J,
Johnson Z,
Lees JA,
Fensome A,
Shavnya A,
Clemens J,
Coffey S,
Blakemore CA,
Avery M,
Tuttle JB,
Hudson P,
Korczynska M,
Murray J,
Williams J,
Xiao J,
Dutra J,
Hernandez D,
Hesp KD,
Mascitti V,
Jagarlapudi S,
Keenan R,
Ward J,
Barnes R,
Jordan E,
Ochocki N,
Callahan D,
Steen K,
Kalgutkar AS,
Fonseca KR,
Sharma R,
Ferguson N,
King-Ahmad A,
Bessire AJ,
Moody A,
Maurer TS,
Stock IA,
Sommese R,
Phillips T,
Loria PM,
Wu H,
Hepworth D,
Sammons MF,
Zhang L,
Zhang Y
(2026) J Med Chem
(2026) J Med Chem
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