EMD-77941

Single-particle
3.0 Å
EMD-77941
3D View Gallery
Deposition: 05/07/2026
Map released: 11/11/2026
Last modified: 11/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-77941

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-36xe summary report (pdf.gz) Map-36xe FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of SLC6A19-ACE2 complex with cinromide

EMD-77941

Single-particle
3.0 Å
EMD-77941
3D View Gallery
Deposition: 05/07/2026
Map released: 11/11/2026
Last modified: 11/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: SLC6A19-ACE2 complex with cinromide
Fitted models: 36xe

Deposition Authors: Wasilko DJ, Lees JA, Wu H
Structure-Guided Discovery of Orally Bioavailable Allosteric SLC6A19 Inhibitors that Promote Urinary Amino Acid Excretion In Vivo
Wang T, Dowling MS, Zhou D, Wasilko DJ, Tu M, Feliers D, Bernardo B, Tillotson J, Ma W, Brown J, Johnson Z, Lees JA, Fensome A, Shavnya A, Clemens J, Coffey S, Blakemore CA, Avery M, Tuttle JB, Hudson P, Korczynska M, Murray J, Williams J, Xiao J, Dutra J, Hernandez D, Hesp KD, Mascitti V, Jagarlapudi S, Keenan R, Ward J, Barnes R, Jordan E, Ochocki N, Callahan D, Steen K, Kalgutkar AS, Fonseca KR, Sharma R, Ferguson N, King-Ahmad A, Bessire AJ, Moody A, Maurer TS, Stock IA, Sommese R, Phillips T, Loria PM, Wu H, Hepworth D, Sammons MF, Zhang L, Zhang Y
(2026) J Med Chem
DOI: doi:10.1021/acs.jmedchem.6c02154
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: