EMD-77939

Single-particle
2.59 Å
EMD-77939
3D View Gallery
Deposition: 05/07/2026
Map released: 11/11/2026
Last modified: 11/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-77939

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-36xc summary report (pdf.gz) Map-36xc FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

NNVL bound to inhibitor compound 112 (YT-IV-239B)

EMD-77939

Single-particle
2.59 Å
EMD-77939
3D View Gallery
Deposition: 05/07/2026
Map released: 11/11/2026
Last modified: 11/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: NVL Hexameric assembly
Fitted models: 36xc

Deposition Authors: Erzberger JP, Cruz VE
Discovery and Optimization of Anticancer Dibenzothiazepinones That Target the Ribosome Biogenesis Factor NVL
Tao Y, Guo HH, Cruz VE, Reddy D, Leach A, Williams NS, Aurora AB, Khivansara V, Han Y, Erzberger JP, Nijhawan D, De Brabander JK
(2026) J Med Chem
DOI: doi:10.1021/acs.jmedchem.6c02184
ISSN: 0022-2623
ASTM: JMCMAR