EMD-76464

Single-particle
2.72 Å
EMD-76464
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Deposition: 07/04/2026
Map released: 15/07/2026
Last modified: 15/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-76464
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 12iz summary report (pdf.gz) Map and 12iz FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human cannabinoid receptor 2-Gi complex with agonist '5249

EMD-76464

Single-particle
2.72 Å
EMD-76464
3D View Gallery
Deposition: 07/04/2026
Map released: 15/07/2026
Last modified: 15/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Complex of the human cannabinoid receptor 2 with heterotrimeric Gi1
Fitted models: 12iz

Deposition Authors: Sacco M, Wu C, Singal B, Skiniotis G
Library Docking for Cannabinoid-2 Receptor Ligands.
Rachman MM, Iliopoulos-Tsoutsouvas C, Sacco MD, Xu X, Wu CG, Santos E, Glenn IS, Paris L, Cahill MK, Ganapathy S, Tummino TA, Moroz YS, Radchenko DS, Okorie M, Tawfik VL, Irwin JJ, Makriyannis A, Skiniotis G, Shoichet BK
(2026) J Med Chem
PUBMED: 42397716
DOI: doi:10.1021/acs.jmedchem.6c00835
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: