Electron Microscopy Data Bank

EMD-76173

Subtomogram averaging
9.6 Å

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Deposition: 17/03/2026
Map released: 09/09/2026
Last modified: 09/09/2026

Overview 3D View Sample Experiment Validation Additional data Links

EMD-76173

In situ subtomogram average of the transition zone linker in human airway cilia (composite map)

EMD-76173

Subtomogram averaging
9.6 Å
EMD-76173

3D View Gallery

Deposition: 17/03/2026
Map released: 09/09/2026
Last modified: 09/09/2026

Overview 3D View Sample Experiment Validation Additional data Links

Sample Organism: Homo sapiens
Sample: Human airway ciliary transition zone (TZ) linker
Fitted models: 11xu

Deposition Authors: Zhou H, Brown A

In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia

Zhou H, Brown A
(2026) Science

DOI: doi:10.1126/science.aei5957
ISSN: 1095-9203
ASTM: SCIEAS

Secondary citations:

Liebschner D, Afonine PV, Baker ML, Bunkoczi G, Chen VB, Croll TI, Hintze B, Hung LW, Jain S, McCoy AJ, Moriarty NW, Oeffner RD, Poon BK, Prisant MG, Read RJ, Richardson JS, Richardson DC, Sammito MD, Sobolev OV, Stockwell DH, Terwilliger TC, Urzhumtsev AG, Videau LL, Williams CJ & Adams PD. (2019) Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix. Acta Crystallogr D Struct Biol,

Grant Support:

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): (United States)
The Giovanni Armenise-Harvard Foundation: (United States)
Richard and Susan Smith Family Foundation: (United States)

EMD-76173

EMD-76173

Archive Files (Depositor)

Validation (wwPDB)

EMDB Annotations

In situ subtomogram average of the transition zone linker in human airway cilia (composite map)

EMD-76173