EMD-75979

Single-particle
2.95 Å
EMD-75979
3D View Gallery
Deposition: 10/03/2026
Map released: 29/07/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75979

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-11rm summary report (pdf.gz) Map-11rm FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human exportin-1 conjugated with FR-027*

EMD-75979

Single-particle
2.95 Å
EMD-75979
3D View Gallery
Deposition: 10/03/2026
Map released: 29/07/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Full-length human XPO1 conjugated to FR-027*
Fitted models: 11rm

Deposition Authors: Wing CE, Fung HYJ, Chook YM
Preclinical characterization of a reversible XPO1 inhibitor for cancer therapy
Van Hauwenhuyse J, Reniers F, Persoons L, Noppen S, Wing CE, Niesman AB, Fung HYJ, Vanstreels E, Jacquemyn M, Boel E, Vankerckhoven A, Berckmans Y, Kwanten B, Coosemans A, Van den Mooter G, Chook YM, Dehaen W, Daelemans D
(2026) Nat Commun
DOI: doi:10.1038/s41467-026-75741-y
ISSN: 2041-1723