EMD-75979
Cryo-EM structure of human exportin-1 conjugated with FR-027*
EMD-75979
Single-particle2.95 Å
Deposition: 10/03/2026Map released: 29/07/2026
Last modified: 09/09/2026
Sample Organism:
Homo sapiens
Sample: Full-length human XPO1 conjugated to FR-027*
Fitted models: 11rm
Deposition Authors: Wing CE
,
Fung HYJ ,
Chook YM
Sample: Full-length human XPO1 conjugated to FR-027*
Fitted models: 11rm
Deposition Authors: Wing CE
,
Fung HYJ ,
Chook YM
Preclinical characterization of a reversible XPO1 inhibitor for cancer therapy.
Van Hauwenhuyse J,
Reniers F ,
Persoons L ,
Noppen S,
Wing CE ,
Niesman AB ,
Fung HYJ ,
Vanstreels E,
Jacquemyn M ,
Boel E,
Vankerckhoven A,
Berckmans Y,
Kwanten B ,
Coosemans A ,
Van den Mooter G,
Chook YM ,
Dehaen W ,
Daelemans D
(2026) Nat Commun , 17
,
Persoons L ,
Noppen S,
Wing CE ,
Niesman AB ,
Fung HYJ ,
Vanstreels E,
Jacquemyn M ,
Boel E,
Vankerckhoven A,
Berckmans Y,
Kwanten B ,
Coosemans A ,
Van den Mooter G,
Chook YM ,
Dehaen W ,
Daelemans D
(2026) Nat Commun , 17
Grant Support:
- Cancer Prevention and Research Institute of Texas (CPRIT): RP220582 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R24GM154185 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM144137 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP210041 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): T32GM131963 (United States)