EMD-75840

Single-particle
2.6 Å
EMD-75840
3D View Gallery
Deposition: 05/03/2026
Map released: 06/05/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75840
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 11mr summary report (pdf.gz) Map and 11mr FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of CRBN in complex with HBS1L and TNG-4857 (focused refinement)

EMD-75840

Single-particle
2.6 Å
EMD-75840
3D View Gallery
Deposition: 05/03/2026
Map released: 06/05/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Dimeric assembly of the ternary complex of CRBN/DDB1 plus HBS1L and TNG-4857
Fitted models: 11mr

Deposition Authors: Whittington DA
TNG961 is a selective oral HBS1L molecular glue degrader for the treatment of FOCAD-deleted cancers.
Nicholson HE, Whittington DA, Bruzzese FJ, Lazarides K, Martires LCM, Tonini MR, Jenkins HN, Zhang M, Shahagadkar P, Pratt CB, Briggs KJ, McCarren P, Tsai A, Bandi M, Min C, Huang A, Zhang H, Meier SR, Shen B, Yu Y, Liang C, Liu Y, Teng T, Zhang J, Crystal A, Mallender WD, Wu XE, Maxwell JP, Andersen JN
(2026) Cancer Discov
PUBMED: 42001523
DOI: doi:10.1158/2159-8290.CD-26-0040
ISSN: 2159-8290
Grant Support: