EMD-75678

Single-particle
3.3 Å
EMD-75678
3D View Gallery
Deposition: 23/02/2026
Map released: 13/05/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75678

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-11gj summary report (pdf.gz) Map-11gj FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human Argonaute2 R315V/H316A - guide10U RNA in complex with a complementary target to position 19

EMD-75678

Single-particle
3.3 Å
EMD-75678
3D View Gallery
Deposition: 23/02/2026
Map released: 13/05/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: human Argonaute-2 R315V/H316A - miR-122(g10U) in complex with a complementary target to position 19
Fitted models: 11gj

Deposition Authors: Sarkar S, Gebert LFR, MacRae IJ
Catalytic activation of human Argonaute 2 requires RNA duplex deformation.
Sarkar S, Gebert LFR, MacRae IJ
(2026) Nat Struct Mol Biol , 33 , 1214 - 1223
PUBMED: 42342972
DOI: doi:10.1038/s41594-026-01840-5
ISSN: 1545-9985