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EMD-75391

Single-particle
2.13 Å
EMD-75391
3D View Gallery
Deposition: 02/02/2026
Map released: 18/03/2026
Last modified: 18/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75391
Download
3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 10qq summary report (pdf.gz) Map and 10qq FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of human VCP/p97 dodecamer bound to ADP (DMSO control)

EMD-75391

Single-particle
2.13 Å
EMD-75391
3D View Gallery
Deposition: 02/02/2026
Map released: 18/03/2026
Last modified: 18/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human VCP/p97 bound to ADP (DMSO control)
Fitted models: 10qq

Deposition Authors: Tamayo-Jaramillo D, Shen PS
Development and Structural Characterization of UTE-156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase.
Tamayo-Jaramillo D, Hegde S, Jia X, Coffman K, Vankayalapati H, Bearss D, Jones KB, Stark AW, Shen PS
(2026) Adv Sci , e20545 - e20545
PUBMED: 41793187
DOI: doi:10.1002/advs.202520545
ISSN: 2198-3844
Grant Support:
  • National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35 GM133772 (United States)
  • National Institutes of Health/National Cancer Institute (NIH/NCI): R01 CA293084 (United States)
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